Key exposome publications

Researchers are entering the third decade of exploring the exposome concept. It is used to describe environmental exposures that an individual encounters throughout their lifetime, and how such exposures may impact biology and health. While a very useful concept, it remains challenging to quantify its aspects, as the exposome encompasses both external and internal factors, including chemical, physical, biological, and social factors that may influence human health. 

The publications below provide a quick, indicative overview of how the exposome field has developed over the past two decades. This list can serve as a useful introduction to the subject for researchers across different disciplines. These publications are not intended to be exhaustive and are presented in reverse chronological order.

Konstantinou, C., et al., 2026. Designing a children’s health exposomics study protocol: The CHILDREN_FIRST multi-country prospective cohort using multi-omics and personalized prevention approaches. Plos One.

Patel, C.J., Ioannidis, J.P.A. & Manrai, A.K. An atlas of exposome–phenome associations in health and disease risk. Nat Med (2026).

Dai, Y., van de Water, B., Telleria, J., Furlong, L.I., Vermeulen, R.C. and Vlaanderen, J., 2026. Integrating human exposome data into next-generation risk assessment: a systematic framework to infer real-life exposure levels and prioritize chemical compounds for testing. Environment International, p.110110. 

Sillé, F., Belkadi, M., Koehler, K., Ali, J., Vasiliou, V., Sarigiannis, D. and Hartung, T., 2026. Charting exposome ethics: a roadmap for the ethical foundations of the human exposome project. Human Genomics. 

Makris, K., Baccarelli, A., Silverman, E., Wright, R., 2025 How exposomic tools complement and enrich genomic research. Cell Genomics, 5(8).

Young, A.S., Mullins, C.E., Sehgal, N., Vermeulen, R.C., Kolijn, P.M., Vlaanderen, J., Rahman, M.L., Birmann, B.M., Barupal, D., Lan, Q. and Rothman, N., 2025. The need for a cancer exposome atlas: a scoping review. JNCI cancer spectrum, 9(1), p.pkae122.

Sarigiannis, D., Karakitsios, S., Anesti, O., Stem, A., Valvi, D., Sumner, S.C., Chatzi, L., Snyder, M.P., Thompson, D.C. and Vasiliou, V., 2025. Advancing translational exposomics: bridging genome, exposome and personalized medicine. Human genomics, 19(1), p.48.

de Hoogh, K., Hoek, G., Flückiger, B., Bussalleu, A., Vienneau, D., Jeong, A., Probst-Hensch, N., de Pinho, M.G.M., Mackenbach, J.D., Lakerveld, J. and Beulens, J.W., 2025. A Europe-wide characterization of the external exposome: A spatio-temporal analysis. Environment International, 200, p.109542.

Hartung, T., 2025. How AI can deliver the human exposome project. Nature medicine, 31(6), pp.1738-1738.

Shao, K., Zou, R., Zhang, Z., Mandemaker, L.D., Timbie, S., Smith Jr, R.D., Durkin, A.M., Dusza, H.M., Meirer, F., Weckhuysen, B.M. and Alderete, T.L., 2025. Advancements in assays for micro-and nanoplastic detection: paving the way for biomonitoring and exposomics studies. Annual Review of Pharmacology and Toxicology, 65(1), pp.567-585. 

Hernandez, H., Santamaria-Garcia, H., Moguilner, S., Farina, F.R., Legaz, A., Prado, P., Cuadros, J., Gonzalez, L., Gonzalez-Gomez, R., Migeot, J. and Coronel-Oliveros, C., 2025. The exposome of healthy and accelerated aging across 40 countries. Nature medicine, 31(9), pp.3089-3100.

Lefèvre-Arbogast, S., Chaker, J., Mercier, F., Barouki, R., Coumoul, X., Miller, G.W., David, A. and Samieri, C., 2024. Assessing the contribution of the chemical exposome to neurodegenerative disease. Nature Neuroscience, 27(5), pp.812-821. 

Miller, G., Banbury Exposomics consortium, 2024. Integrating exposomics into biomedicine. Science, 388, pp.356-358.

Fayet, Y., Bonnin, T., Canali, S. and Giroux, E., 2024. Putting the exposome into practice: an analysis of the promises, methods and outcomes of the European human exposome network. Social Science & Medicine, 354, p.117056. 

Safarlou, C.W., Jongsma, K.R. and Vermeulen, R., 2024. Reconceptualizing and defining exposomics within environmental health: expanding the scope of health research. Environmental Health Perspectives, 132(9), p.095001. 

Foreman, A.L., Warth, B., Hessel, E.V., Price, E.J., Schymanski, E.L., Cantelli, G., Parkinson, H., Hecht, H., Klánová, J., Vlaanderen, J. and Hilscherova, K., 2024. Adopting mechanistic molecular biology approaches in exposome research for causal understanding. Environmental science & technology, 58(17), pp.7256-7269. 

Merra, G., Gualtieri, P., La Placa, G., Frank, G., Della Morte, D., De Lorenzo, A. and Di Renzo, L., 2024. The relationship between exposome and microbiome. Microorganisms, 12(7), p.1386. 

Safarlou, C.W., Jongsma, K.R., Vermeulen, R. and Bredenoord, A.L., 2023. The ethical aspects of exposome research: a systematic review. Exposome, 3(1), p.osad004.

Karlsson, O., 2023. Chemical safety and the exposome. Emerging Contaminants, 9(2), p.100225. 

Hartung, T., 2023. A call for a human exposome project. ALTEX-Alternatives to animal experimentation, 40(1), pp.4-33. 

Barouki, R., Samson, M., Blanc, E.B., Colombo, M., Zucman-Rossi, J., Lazaridis, K.N., Miller, G.W. and Coumoul, X., 2023. The exposome and liver disease-how environmental factors affect liver health. Journal of hepatology, 79(2), pp.492-505. 

Muenzel, T., Sørensen, M., Hahad, O., Nieuwenhuijsen, M. and Daiber, A., 2023. The contribution of the exposome to the burden of cardiovascular disease. Nature Reviews Cardiology, 20(10), pp.651-669. 

Maitre, L., Bustamante, M., Hernández-Ferrer, C., Thiel, D., Lau, C.H.E., Siskos, A.P., Vives-Usano, M., Ruiz-Arenas, C., Pelegrí-Sisó, D., Robinson, O. and Mason, D., 2022. Multi-omics signatures of the human early life exposome. Nature communications, 13(1), p.7024.

Barouki, R., Audouze, K., Becker, C., Blaha, L., Coumoul, X., Karakitsios, S., Klanova, J., Miller, G.W., Price, E.J. and Sarigiannis, D., 2022. The exposome and toxicology: a win–win collaboration. Toxicological Sciences, 186(1), pp.1-11. 

Price, E.J., Vitale, C.M., Miller, G.W., David, A., Barouki, R., Audouze, K., Walker, D.I., Antignac, J.P., Coumoul, X., Bessonneau, V. and Klanova, J., 2022. Merging the exposome into an integrated framework for “omics” sciences. IScience, 25(3). 

Vineis, P. and Barouki, R., 2022. The exposome as the science of social-to-biological transitions. Environment International, 165, p.107312. 

Beulens, J.W., Pinho, M.G., Abreu, T.C., den Braver, N.R., Lam, T.M., Huss, A., Vlaanderen, J., Sonnenschein, T., Siddiqui, N.Z., Yuan, Z. and Kerckhoffs, J., 2022. Environmental risk factors of type 2 diabetes—an exposome approach. Diabetologia, 65(2), pp.263-274. 

David, A., Chaker, J., Price, E.J., Bessonneau, V., Chetwynd, A.J., Vitale, C.M., Klánová, J., Walker, D.I., Antignac, J.P., Barouki, R. and Miller, G.W., 2021. Towards a comprehensive characterisation of the human internal chemical exposome: Challenges and perspectives. Environment International, 156, p.106630. 

Vermeulen, R., Schymanski, E.L., Barabási, A.L. and Miller, G.W., 2020. The exposome and health: Where chemistry meets biology. Science, 367(6476), pp.392-396. 

Vrijheid, M., Fossati, S., Maitre, L., Márquez, S., Roumeliotaki, T., Agier, L., Andrusaityte, S., Cadiou, S., Casas, M., de Castro, M. and Dedele, A., 2020. Early-life environmental exposures and childhood obesity: an exposome-wide approach. Environmental health perspectives, 128(6), p.067009. 

Vineis, P., Robinson, O., Chadeau-Hyam, M., Dehghan, A., Mudway, I. and Dagnino, S., 2020. What is new in the exposome?. Environment international, 143, p.105887. 

  • Exposome-wide analyses and risk of B-Cell Lymphoma (2019 and 2021) 

Vermeulen, R., 2019. Association between anthropometry and lifestyle factors and future risk of B cell lymphoma; an exposome wide analyses. Environmental Epidemiology, 3, pp.345-346. 

Saberi Hosnijeh, F., Casabonne, D., Nieters, A., Solans, M., Naudin, S., Ferrari, P., Mckay, J.D., Benavente, Y., Weiderpass, E., Freisling, H. and Severi, G., 2021. Association between anthropometry and lifestyle factors and risk of B‐cell lymphoma: An exposome‐wide analysis. International journal of cancer, 148(9), pp.2115-2128. 

Nieuwenhuijsen, M.J., Agier, L., Basagaña, X., Urquiza, J., Tamayo-Uria, I., Giorgis-Allemand, L., Robinson, O., Siroux, V., Maitre, L., de Castro, M. and Valentin, A., 2019. Influence of the urban exposome on birth weight. Environmental health perspectives, 127(4), p.047007. 

Rattray, N.J., Deziel, N.C., Wallach, J.D., Khan, S.A., Vasiliou, V., Ioannidis, J.P. and Johnson, C.H., 2018. Beyond genomics: understanding exposotypes through metabolomics. Human genomics, 12(1), p.4. 

Cecchi, L., D’Amato, G. and Annesi-Maesano, I., 2018. External exposome and allergic respiratory and skin diseases. Journal of Allergy and Clinical Immunology, 141(3), pp.846-857. 

Guloksuz, S., van Os, J. and Rutten, B.P., 2018. The exposome paradigm and the complexities of environmental research in psychiatry. JAMA psychiatry, 75(10). 

Andrianou, X.D. and Makris, K.C., 2018. The framework of urban exposome: application of the exposome concept in urban health studies. Science of the total environment, 636, pp.963-967. 

Dai, D., Prussin, A.J., Marr, L.C., Vikesland, P.J., Edwards, M.A. and Pruden, A., 2017. Factors shaping the human exposome in the built environment: opportunities for engineering control. Environmental Science & Technology, 51(14), pp.7759-7774. 

Loh, M., Sarigiannis, D., Gotti, A., Karakitsios, S., Pronk, A., Kuijpers, E., Annesi-Maesano, I., Baiz, N., Madureira, J., Oliveira Fernandes, E. and Jerrett, M., 2017. How sensors might help define the external exposome. International Journal of Environmental Research and Public Health, 14(4), p.434. 

Siroux, V., Agier, L. and Slama, R., 2016. The exposome concept: a challenge and a potential driver for environmental health research. European Respiratory Review, 25(140), pp.124-129. 

Robinson, O. and Vrijheid, M., 2015. The pregnancy exposome. Current environmental health reports, 2(2), pp.204-213. 

Rappaport, S.M., Barupal, D.K., Wishart, D., Vineis, P. and Scalbert, A., 2014. The blood exposome and its role in discovering causes of disease. Environmental health perspectives, 122(8), p.769. 

Nakamura, J., Mutlu, E., Sharma, V., Collins, L., Bodnar, W., Yu, R., Lai, Y., Moeller, B., Lu, K. and Swenberg, J., 2014. The endogenous exposome. DNA repair, 19, pp.3-13. 

Vrijheid, M., 2014. The exposome: a new paradigm to study the impact of environment on health. Thorax, 69(9), pp.876-878. 

Wild, C.P., Scalbert, A. and Herceg, Z., 2013. Measuring the exposome: a powerful basis for evaluating environmental exposures and cancer risk. Environmental and molecular mutagenesis, 54(7), pp.480-499. 

Rappaport, S.M., 2012. Biomarkers intersect with the exposome. Biomarkers, 17(6), pp.483-489. 

Wild, C.P., 2012. The exposome: from concept to utility. International journal of epidemiology, 41(1), pp.24-32. 

Lioy, P.J. and Rappaport, S.M., 2011. Exposure science and the exposome: an opportunity for coherence in the environmental health sciences. Environmental health perspectives, 119(11), p.a466. 

Rappaport, S.M., 2011. Implications of the exposome for exposure science. Journal of exposure science & environmental epidemiology, 21(1), pp.5-9. 

Wild, C.P., 2005. Complementing the genome with an “exposome”: the outstanding challenge of environmental exposure measurement in molecular epidemiology. Cancer Epidemiology Biomarkers & Prevention, 14(8), pp.1847-1850.